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國際罕見疾病中心

莊志光

研究員

莊志光醫師

  • 現職

    • Researcher, and Technical Chief of Medical Research Department, MacKay Memorial Hospital, Taipei, Taiwan. From 1994 - present (研究員暨技術主任)
    • Associate Professor, Department of Nursing and Holistic Education Center, Fu Jen Catholic University, Xinzhuang Dist., New Taipei City, 24205 Taiwan. From 1991 ~ present (副教授)
    • Associate Professor, Department of Department of Food Science, Nutrition and Nutraceutical Biotechnology, College of Human Ecology, Shih Chien University, Taipei, Taiwan. From 2008 ~ present (副教授)

  • 主要學歷

    • B. S. 1987-1990 University of Kansas. Medical Technology.
    • M. S. 1990-1992 Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA. Medical Technology.
    • Ph.D. 2009-2013 National Taipei University of Technology, Biochemical and Biomedical Engineering.
    • Research Training, 1996-1996, Department of Genetics, Duke University, NC, USA.
    • Research Training, 1998-1999, Willink Biochemical Genetics Unit, Manchester Children Hospital, UK.

    主要經歷

    • Researcher, and Technical Chief of Medical Research Department, MacKay Memorial Hospital, Taipei, Taiwan. From 1994 ~ present (研究員暨技術主任)
    • Associate Professor, Department of Nursing and Holistic Education Center, Fu Jen Catholic University, Xinzhuang Dist., New Taipei City, 24205 Taiwan. From 1991 ~ present (副教授)
    • Associate Professor, Department of Department of Food Science, Nutrition and Nutraceutical Biotechnology, College of Human Ecology, Shih Chien University, Taipei, Taiwan. From 2008 ~ present (副教授)

執行項目或專長

MAJOR SERVICE

其他相關

Research Projects (2013-2015)

  • A pilot study for newborn screening of mucopolysaccharidosis IV in Taiwan, and R/D for multiplexing of different MPS types using Bio-Plex Immunoassay System. Ministry of Science and Technology, Taiwan., 2015/8/1 ~ 2016/7/31 (Mackay Memorial Hospital Grant #105-55); Principle Investigator
  • To decipher the Alzheimer's complication in Down Syndrome patients by detecting blood beta amyloid 42, 40, and Tau protein by immunomagnetic reduction assay. Ministry of Science and Technology, Taiwan., 2015/8/1 ~ 2016/7/31 (NSC-104-2314-B-195-019-), and MacKay Memorial Hospital (MMH #105-25); Co-Principle Investigator
  • New modified carnitine acetyltransferase long-wavelength latent fluorometric assay for plasma free/total carnitine quantification. MacKay Memorial Hospital, (MMH #104-45), 2014/8/1 ~ 2015/7/31; Principle Investigator
  • Phenotype and Genotype/Epigenotype Analysis and DNA Methylation Studies in Imprinting Disorders. Ministry of Science and Technology, Taiwan (NSC 102-2314-B-195-017-MY3), and MacKay Memorial Hospital (MMH #105-26), 2013/8/1 ~ 2016/7/31; Co-Principle Investigator
  • The tandem mass study of mucopolysaccharidosis and its clinical application. MacKay Memorial Hospital, (MMH #103-52), 2013/8/1 ~ 2014/7/31; Principle Investigator
  • Study of multiplex assay applied simultaneously for MPS newborn screening test. Ministry of Science and Technology, Taiwan (NSC 102-2314-B-195-006-), and MacKay Memorial Hospital (MMH #103-13), 2013/8/1 ~ 2014/7/31; Co-Principle Investigator
  • Triplex Tandem Mass Spectrometry Assays of Lysosomal Enzyme Activities in Dried Blood Spots: A Pilot Newborn Screening Study of Pompe, Fabry, and Hurler Diseases. MacKay Memorial Hospital, (MMH #102-47), 2013/1/1 ~ 2013/12/31; Principle Investigator

論文研究

論文研究: (2013年起~)

  1. Lin HY, Chuang CK, Su YN, Chen MR, Chiu HC, Niu DM, Lin SP. Genotype and phenotype analysis of Taiwanese patients with osteogenesis imperfecta. Orphanet J Rare Dis. 2015 Dec 1;10:152.
  2. Lin HY, Chuang CK*, Chen YJ, Tu RY, Chen MR, Niu DM, Lin SP. Functional independence of Taiwanese children with Down syndrome. Dev Med Child Neurol. 2015 Sep 2. doi: 10.1111/dmcn.12889.
  3. Ho TC, Chiang YP, Chuang CK, Chen SL, Hsieh JW, Lan YW, Tsao YP. PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells. Am J Physiol Cell Physiol. 2015 Aug 1;309(3):C159-68.
  4. Lin CJ, Lin J, Pan CF, Chuang CK, Liu HL, Sun FJ, Wang TJ, Chen HH, Wu CJ. Indoxyl sulfate, not P-cresyl sulfate, is associated with advanced glycation end products in patients on long-term hemodialysis. Kidney Blood Press Res. 2015;40(2):121-9. doi: 10.1159/000368488. Epub 2015 Mar 19. PubMed PMID: 25833743.
  5. Lin YJ, Ho CS, Hsu CH, Lin JL, Chuang CK, Tsai JD, Chiu NC, Lin HY, Lin SP. A Truncating De Novo Point Mutation in a Young Infant with Severe Menkes Disease. Pediatr Neonatol. 2014 Nov 14. pii: S1875-9572(14)00172-7. doi: 10.1016/j.pedneo.2014.05.008. [Epub ahead of print] PubMed PMID: 25771438.
  6. Yeung CY, Lee HC, Chan WT, Jiang CB, Chang SW, Chuang CK. Vertical transmission of hepatitis C virus: Current knowledge and perspectives. World J Hepatol. 2014 Sep 27;6(9):643-51. doi: 10.4254/wjh.v6.i9.643. Review. PubMed PMID: 25276280; PubMed Central PMCID: PMC4179143.
  7. Chuang CK, Lin HY, Wang TJ, Tsai CC, Liu HL, Lin SP. A modified liquid chromatography/tandem mass spectrometry method for predominant disaccharide units of urinary glycosaminoglycans in patients with mucopolysaccharidoses. Orphanet J Rare Dis. 2014 Sep 2;9:135. doi: 10.1186/s13023-014-0135-3. PubMed PMID:25178307; PubMed Central PMCID: PMC4164790.
  8. Lin HY, Lo CI, Chuang CK, Lin SP. Mucopolysaccharidosis I (Scheie syndrome): A rare cause of severe aortic stenosis in a 31-year-old man. J Formos Med Assoc. 2015 Oct;114(10):1015-6.
  9. Lin SM, Lin HY, Chuang CK, Lin SP, Chen MR. Cardiovascular abnormalities in Taiwanese patients with mucopolysaccharidosis. Mol Genet Metab. 2014 Apr;111(4):493-8. doi: 10.1016/j.ymgme.2014.02.009. Epub 2014 Feb 21. PubMed PMID: 24598247.
  10. Lin HY, Shih SC, Chuang CK, Lee KS, Chen MR, Lin HC, Chiu PC, Niu DM, Lin SP. Assessment of hearing loss by pure-tone audiometry in patients with mucopolysaccharidoses. Mol Genet Metab. 2014 Apr;111(4):533-8. doi: 10.1016/j.ymgme.2014.02.003. Epub 2014 Feb 16. PubMed PMID: 24594444.
  11. Lin CJ, Pan CF, Chuang CK, Sun FJ, Wang DJ, Chen HH, Liu HL, Wu CJ. P-cresyl sulfate is a valuable predictor of clinical outcomes in pre-ESRD patients. Biomed Res Int. 2014;2014:526932. doi: 10.1155/2014/526932. Epub 2014 Jan 29. PubMed PMID: 24592393; PubMed Central PMCID: PMC3925630.
  12. Lin HY, Chuang CK*, Chen MR, Chiu PC, Ke YY, Niu DM, Tsai FJ, Hwu WL, Lin JL, Lin SP. Natural history and clinical assessment of Taiwanese patients with mucopolysaccharidosis IVA. Orphanet J Rare Dis. 2014 Feb 10;9:21. doi: 10.1186/1750-1172-9-21. PubMed PMID: 24513086; PubMed Central PMCID: PMC3925123.
  13. Comparison of free fatty acid content of human milk from Taiwanese mothers and infant formula. Taiwan J Obstet Gynecol. 2013 Dec; 52(4):527-33.
  14. Lin CJ, Pan CF, Chuang CK, Liu HL, Sun FJ, Wang TJ, Chen HH, Wu CJ. Gastrointestinal-related uremic toxins in peritoneal dialysis: a pilot study with a 5-year follow-up. Arch Med Res. 2013 Oct; 44(7):535-41.
  15. Lin SP, Lin HY, Wang TJ, Chang CY, Lin CH, Huang SF, Tsai CC, Liu HL, Keutzer J, Chuang CK*. A pilot newborn screening program for Mucopolysaccharidosis type I in Taiwan. Orphanet J Rare Dis. 2013 Sep 22; 8:147.
  16. Lin CJ, Chuang CK, Jayakumar T, Liu HL, Pan CF, Wang TJ, Chen HH, Wu CJ. Serum p-cresyl sulfate predicts cardiovascular disease and mortality in elderly hemodialysis patients. Arch Med Sci. 2013 Aug 30; 9(4):662-8.
  17. Lin HY, Shih SC, Chuang CK, Chen MR, Niu DM, Lin SP. Assessment of bone mineral density by dual energy x-ray absorptiometry in patients with mucopolysaccharidoses. Orphanet J Rare Dis. 2013 May 11; 8:71.
  18. Lin SP, Shih SC, Chuang CK, Lee KS, Chen MR, Niu DM, Chiu PC, Lin SJ, Lin HY. Characterization of pulmonary function impairments in patients with mucopolysaccharidoses-changes with age and treatment. Pediatr Pulmonol. 2014 Mar; 49(3):277-84.
  19. Lin DS, Chiang MF, Ho CS, Hsiao CD, Lin CY, Wang NL, Chuang CK, Huang YW, Chang PC, Liu HL. Low-frequency enzyme replacement therapy in late-onset Pompe disease. Muscle Nerve. 2013 Apr; 47(4):612-3.

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