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血液暨腫瘤科

  • 陳功深醫師相片

    陳功深

    主治醫師

    血液暨腫瘤科 :
    台北門診掛號  淡水門診掛號
    癌症中西整合門診 :
    淡水門診掛號

    陳功深醫師本頁二維碼

  • 現職

      馬偕紀念醫院 血液腫瘤科 資深主治醫師


    主要學歷

      英國南安普敦大學 腫瘤免疫學博士


    主要經歷

      清華大學 分子醫學研究所副教授
      馬偕醫學院 助理教授
      腫瘤內科專科醫師
      血液病專科醫師
      內科專科醫師

    其他相關

      <學會會員>
      台灣內科醫學會
      中華民國癌症醫學會
      中華民國血液病學會
      台灣安寧緩和醫學會
      <證書>
      醫師證書
      內科專科醫師證書
      中華民國血液病專科醫師證書
      中華民國腫瘤內科專科醫師證書

主治項目或專長

轉移癌症、血液病,貧血、白血病、淋巴瘤、腫瘤免疫治療。


論文研究

  1. Wang C, Su NW, Hsu K, Kao CW, Chang MC, Chang YF, Lim KH, Chiang YH, Chang YC, Sung MT, Wu HH, Chen CG*. The implication of serum HLA-G in angiogenesis of multiple myeloma. Mol Med. 2024 Jun 14;30(1):86. doi: 10.1186/s10020-024-00860-5.

  2. Chang YC, Chiang YH, Hsu K, Chuang CK, Kao CW, Chang YF, Chang MC, Lim KH, Cheng HI, Hsu YN, Chen CG*. Activated naïve γδ T cells accelerate deep molecular response to BCR-ABL inhibitors in patients with chronic myeloid leukemia. Blood Cancer Journal 2021 Nov 16; 11(11): 182.

  3. Lim KH, Wu JN, Huang TY, Jhuang JY, Chang YC, Lin HC, Chiang YH, Su YW, Chen CG*, Chang YF, Lim J. Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing. Blood Adv. 2021 Mar 23; 5(6): 1733-36

  4. Lim KM, Chen LC, Hsu K, Chang CC, Chang CY, Kao CW, Chang YF, Chang MC, Chen CG*. BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death & Disease 2020 Oct 1; 11(9): 820. 

  5. Chang MC, Cheng HI, Hsu K, Hsu YN, Kao CW, Chang YF, Lim KH,Chen CG*. NKG2A down-regulation by Dasatinib enhances natural killer cytotoxicity and accelerates effective treatment responses in patients with chronic myeloid leukemia. Front Immunol. 2019 Jan 17; 9:3152.

  6. Chang MC, Cheng HI, Hsu K, Hsu YN, Kao CW, Chang YF, Lim KH, Chen CG*. NKG2A down-regulation by Dasatinib enhances natural killer cytotoxicity and accelerates effective treatment responses in patients with chronic myeloid leukemia. Front Immunol. 2019 Jan 17; 9:3152.

  7. Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen*, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang and Yi-Fang Chang. STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFRpositive colorectal cancers: RNAseq analysis and therapeutic screening. Journal of Biomedical Science. 2018 25:60.
  8. Chun-Chia Cheng, Kuei-Fang Chou, Cheng-Wen Wu, Nai-Wen Su, Cheng-Liang Peng, Ying-Wen Su, Jungshan Chang, Ai-Sheng Ho, Huan-Chau Lin, Caleb Gon- Shen Chen*, Bi-Ling Yang, Yu-Cheng Chang, Ya-Wen Chiang, Ken-Hong Lim, Yi-Fang Chang . EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer. Lung Cancer, 2018 Feb; 116:80-89.
  9. Chun-Chia Cheng, Hsin-Chi Lin, Kaun-Jer Tsai, Ya-Wen Chiang, Ken-Hong Lim, Caleb Gon-Shen Chen*, Ying-Wen Su, Cheng-Liang Peng, Ai-Sheng Ho, Ling Huang, Yu-Cheng Chang, Huan-Chau Lin, Jungshan Chang, Yi-Fang Chang. Epidermal growth factor induces STAT1 expression to exacerbate the IFNr-mediated PD-L1 axis in epidermal growth factor receptorpositive cancers. Molecular Carcinogenesis. 2018 Nov; 57(11):1588-1598.
  10. Chiang YH, Chang YC, Lin HC, Huang L, Cheng CC, Wang WT, Cheng HI, Su NW, Chen CG*, Lin J, Chang YF, Chang MC, Hsieh RK, Chou WC, Lim KH, Kuo YY . Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population. Oncotarget. 2017 Sep 29; 8(44): 76204–76213.
  11. Lim KH, Chen CG*, Chang YC, Chiang YH, Kao CW, Wang WT, Chang CY, Huang L, Lin CS, Cheng CC, Cheng HI, Su NW, Lin J, Chang YF, Chang MC, Hsieh RK, Lin HC, Kuo YY. Increased B cell activation is present in JAK2V617F- mutated, CALR-mutated and triple-negative essential thrombocythemia. Oncotarget. 2017 May16;8(20):32476- 32491.
  12. Lim KH, Chang YC, Chiang YH, Lin HC, Chang CY, Lin CS, Huang L, Wang WT, Gon-Shen Chen*, Chou WC, Kuo YY. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood Cancer J. 2016 Oct 7;6(10):e481.
  13. TZEON-JYE CHIOU, YI-FANG CHANG, MING-CHUNG WANG, CHENWEI KAO, HSUAN-YU LIN, TSAI-YUN CHEN, ERH-JUNG HSUEH, YIIJENQ LAN, YUNG-CHUAN SUNG, SHENG-FENG LIN, LI-YUAN BAI, and CALEB G. CHEN* . Eltrombopag enhances platelet adhesion by upregulating the expression of glycoprotein VI in patients with chronic immune thrombocytopenic purpura. Translational Research,2015,Dec 166: 750-761.
  14. Lim KH, Lin HC, Chen CG*, Wang WT, Chang YC, Chiang YH2, Lin CS, Su NW, Su YW, Lin J, Chang YF, Chang MC, Hsieh RK, Kuo YY, Chou WC. Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis. Clin Chim Acta 2015 Feb 2; 440:133-9.
  15. Lim KH, Chang YC, Gon-Shen Chen*, Lin HC, Wang WT, Chiang YH, Cheng HI, Su NW, Lin J, Chang YF, Chang MC, Hsieh RK, Kuo YY, Chou WC. Frequent CALR exon 9 alterations in JAK2 V617F-mutated essential thrombocythemia detected by high-resolution melting analysis. Blood Cancer J. 2015 Mar 20;5:e295.
  16. Hsueh-Liang Chu, Tsai-Mu Cheng, Hung-Wei Chen, Fu-Hsuan Chou, Yu-Chuan Chang, Hsin-Yu Lin, Shih-Yi Liu, Yu-Chuan Liang, Ming-Hua Hsu, Dian-Shyeu Wu, Hsing-Yuan Li, Li-Ping Ho, Ping-Ching Wu, Fu-Rong Chen, Gong-Shen Chen*, Dar-Bin Shieh, Chia-Seng Chang, Chia-Hao Su, Zemin Yao, and Chia-Ching Chang. Synthesis of Apolipoprotein B Lipoparticles to Deliver Hydrophobic/Amphiphilic Materials. ACS Appl. Mater. Interfaces 2013; 5: 7509−7516.
  17. Huan-Chau Lin , Shu-Ching Wang, Caleb Gon-Shen Chen* , Ming-Chih Chang,Wei-Ting Wang, Nai-Wen Su, Hung-I Cheng , Johnson Lin, Yi-Fang Chang , Ruey-Kuen Hsieh, Chien-Chung Chang , Yuchi Hwang, Ken-Hong Lim, Yuan-Yeh Kuo. Mutation and Lineage 2013, Jan.,Huang HL, Yeh CN, Chang KW, Chen JT, Lin KJ, Chiang LW, Jeng KC, Wang WT, Lim KH, Chen CG*, Lin KI, Huang YC, Lin WJ, Yen TC, Yu CS. Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase. Bioorg Med Chem Lett 2012;22(12):3998-4003.
  18. Chen CG*, Lu YT, Lin M, Savelyeva N, Stevenson FK, Zhu D. Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin. Vaccine. 2009 Jul 9;27(32):4289-96.
  19. C Chen*, MC Chang, YF Chang, KW Tsan. Activation of CD44 Facilitates DNA Repair in T-cell Lymphoma but has Differential Effects on Apoptosis Induced by Chemotherapeutic Agents and Ionizing Radiation. Leukemia & Lymphoma 2005;46(12): 1785-1795.