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麻醉部

  • 鄭仁坤醫師相片

    鄭仁坤

    資深主治醫師



    鄭仁坤醫師本頁二維碼

  • 現職

      • 麻醉部資深主治醫師
      • 馬偕醫學院醫學系專任教授/麻醉學科主任

    主要學歷

      • 國立陽明醫學院 醫學系
      • 台灣大學藥理學研究所博士

    主要經歷

      • John Bonica Fellowship Award, IASP (2006)
      • Preceptorship, Toronto Western Hospital, Canada. (April, 2006)
      • Research fellow, Wake Forest University, NC, USA (1998/7-1999/6); Brigham and Women's Hospital, Boston, USA (2007/7-2008/6)
      • Asian Journal of Anesthesiology 編輯委員
      • 疼痛專科醫師甄審委員會委員
      • 麻醉專科醫師甄審委員會/國際學術交流委員會主任委員
      • 台灣麻醉/疼痛醫學會理事/監事
      • 馬偕淡水分院手術室主任(2009/7-2011/6)
      • 馬偕紀念醫院麻醉科/手術室主任(2011/7-2015/6)

主治項目或專長


  • 臨床麻醉

  • 疼痛控制

  • 疼痛研究，藥理學，神經科學，麻醉學


論文研究

  • 1.     Sheng-Jie Shiue, Ruey-Horng Rau, Han-Shiang Shiue, Yi-Wei Hung, Zhi-Xiang Li, Kuender D. Yang, Jen-Kun Cheng*. Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury-induced pain in rats. Pain 2019 Jan; 160(1):210-223. (5.483, 6/32, 17.2%)

  • 2.     S. J. Shiue, H. Y. Peng, C. R. Lin, S. W. Wang, R. H. Rau, Jen-Kun Cheng*. Continuous intrathecal infusion of cannabinoid receptor agonists attenuates nerve ligation-induced pain in rats. Regional Anesthesia and Pain Medicine 2017 Jul/Aug; 42(4):499-506. (*corresponding author) (7.015, 2/32, 4.7%)
  • 3.     Sheng-Jie Shiue, Chi-Hsu Wang, Tao-Yeuan Wang, Yi-Chun Chen, Jen-Kun Cheng*.  Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 up-regulation in nerve-ligated rats. Acta Anaesthesiologica Taiwanica 2016 Dec. 54:81-87. (國科會優良期刊) 
  • 4.     Chau-Fu Cheng, Jen-Kun Cheng, Chih-Yang Chen, Ruey-Horng Rau, Yu-Cheng Chang, Meei-Ling Tsaur. Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain. Pain 2015 Nov. 156(11):2295-309. (5.483, 6/32, 17.2%)
  • 5.     Y. L. Chen, M. L. Tsaur, S. W. Wang, T. Y. Wang, Y. C. Hung, C. S. Lin, Y. F. Chang, Y. C. Wang, S. J. Shiue, Jen-Kun    Cheng*. Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats. British Journal of Anaesthesia 2015 Jul; 115(1):105-11. (6.88, 3/32, 7.8%)
  • 6.     Chau-Fu Cheng*, Jen-Kun Cheng*, Chih-Yang Chen, Cheng-Chang Lien, Dachen Chu, Szu-Yi Wang, Meei-Ling Tsaur. Mirror-image pain is mediated by NGF produced from TNFa-activated satellite glia after peripheral nerve injury. Pain 2014 May; 155(5):906-20. (*Co-first author) (IF: 5.559, 3/31, 9.7%)
  • 7.     Wen YR, Tan PH, Jen-Kun Cheng, Liu YC, Ji RR. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011 Aug;110(8):487-94 (review)
  • 8.     Li-Chuan Chu, Meei-Ling Tsaur, Chia-Shiang Lin, Yu-Chun Hung, Tao-Yeuan Wang, Chien-Chuan Chen, Jen-Kun Cheng*. Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia 2011 May; 106(5):699-705. (*corresponding author)
  • 9.     Yong-Jing Gao,* Jen-Kun Cheng*, Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Experimental Neurology 2009 Sep; 219(1):146-55. (*first authors of equal contribution) 
  • 10. Chih-Fu Lin, Meei-Ling Tsaur, Chia-Shiang Lin, Chien-Chuan Chen, Yung-Jen Huang, Jen-Kun Cheng*. Intrathecal gabapentin does not act as an HCN channel activator in the rat formalin test. European Journal of Anaesthesiology 2009; 26(10):821-4. (*corresponding author) 
  • 11. Yasuhiko Kawasaki,* Ling Zhang,* Jen-Kun Cheng, Ru-Rong Ji. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. The Journal of Neuroscience 2008 May 14; 28(20):5189-94. (*first authors of equal contribution) 
  • 12. Tatsuro Kohno,* Haibin Wang,* Fumimasa Amaya, Gary J. Brenner, Jen-Kun Cheng, Ru-Rong Ji, Clifford J. Woolf. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. The Journal of Neuroscience 2008 Apr. 23; 28(17):4533-40. (*first authors of equal contribution) 
  • 13. Jen-Kun Cheng, Ru-Rong Ji. Intracellular signaling in primary sensory neurons and persistent pain. Neurochemical Research 2008 Oct. 33(10):1970-8. (review) 
  • 14. Li-Ying Chien*, Jen-Kun Cheng*, Dachen Chu, Chau-Fu Cheng, Meei-Ling Tsaur. Reduced Expression of A-type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity. The Journal of Neuroscience 2007 Sep. 27(37):9855-9865. (*first authors of equal contribution)
  • 15. Lin CS, Tsaur ML, Chen CC, Wang TY, Lin CF, Lai YL, Hsu TC, Pan YY, Yang CH, Jen-Kun Cheng*. Chronic intrathecal infusion of minocycline prevents the development of spinal nerve ligation-induced pain in rats. Regional Anesthesia and Pain Medicine 2007 May-Jun; 32(3):209-16. (*corresponding author)
  • 16. Jen-Kun Cheng, Chia-Shiang Lin, Chien-Chuan Chen, Jia-Rung Yang, Lih-Chu Chiou. Effects of Intrathecal Injection of T-Type Calcium Channel Blockers in the Rat Formalin Test. Behavioural Pharmacology 2007 Feb. 18(1):1-8. (supported by NSC 94-2314-B-195 –006)