細胞與再生醫療中心
主治項目或專長
肺癌、乳癌、胃腸道癌症、泌尿道癌症及其它各類惡性腫瘤、轉移癌症、血液病(貧血、白血病、淋巴瘤、紫瘢症及骨髓造血不良症候群)、老人腫瘤醫學癌症安寧緩和醫療及免疫治療。
論文研究
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Lim KH, Wu JN, Huang TY, Jhuang JY, Chang YC, Lin HC*, Chiang YH, Su YW, Chen GS, Chang YF, Lim J. Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing. Blood Adv. 2021 Mar 23; 5(6): 1733-36
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Lai YH, Audira G, Liang ST, Siregar P, Suryanto ME, Lin HC*, Villalobos O, Villaflores OB, Hao E, Lim KH, Hsiao CD. Duplicated dnmt3aa and dnmt3ab DNA methyltransferase genes play essential and non-overlapped functions on modulating behavioral control in zebrafish. Genes. 2020 Nov 7;11(11):1322.
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Cheng CC,Lin HC*, Chiang YW, Chang J, Sie ZL, Yang BL, Lim KH, Peng CL, Ho AS, Chang YF. Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer Immunol Immunother. 2021 May 70(5): 1351-64.
- Cheng CC, Liao PN, Ho AS, Lim KH, Chang J, Su YW, Chen CG, Chiang YW, Yang BL, Lin HC*, Chang YC, Chang CC, Chang YF. STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening. J Biomed Sci. 2018 Aug 2; 25(1):60.
- Cheng CC, Lin HC*, Tsai KJ, Chiang YW, Lim KH, Chen CG, Su YW, Peng CL, Ho AS, Huang L, Chang YC, Lin HC, Chang J, Chang YF. Epidermal growth factor induces STAT1 expression to exacerbate the IFNr-mediated PD-L1 axis in epidermal growth factor receptor-positive cancers. Mol Carcinog. 2018 Nov; 57(11):1588-98.
- Cheng CC, Chou KF, Wu CW, Su NW, Peng CL, Su YW, Chang J, Ho AS, Lin HC*, Chen CG, Yang BL, Chang YC, Chiang YW, Lim KH, Chang YF. EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer. Lung Cancer. 2018 Feb; 116: 80-89.
- Shih BB, Chang YF, Cheng CC, Yang HJ, Chang KW, Ho AS, Lin HC*, Yeh C, Chang CC. SPECT imaging evaluation of 111indium-chelated cetuximab for diagnosing EGFR-positive tumor in an HCT-15-induced colorectal xenograft. J Chin Med Assoc. 2017 Dec; 80(12):766-73.
- Cheng CC, Chang J, Huang SC, Lin HC*, Ho AS, Lim KH, Chang CC, Huang L, Chang YF, Wu CW. YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells. PLoS One. 2017 Aug; 12(8):e0182149.
- Chiang YH, Chang YC, Lin HC*, Huang L, Cheng CC, Wang WT, Cheng HI, Su NW, Chen CG, Lin J, Chang YF, Chang MC, Hsieh RK, Chou WC, Lim KH, Kuo YY. Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population. Oncotarget. 2017 Jul 12.
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Lim KH, Chen CG, Chang YC, Chiang YH, Kao CW, Wang WT, Chang CY, Huang L, Lin CS, Cheng CC, Cheng HI, Su NW, Lin J, Chang YF, Chang MC, Hsieh RK, Lin HC*, Kuo YY. Increased B cell activation is present in JAK2V617F-mutated, CALR-mutated and triple-negative essential thrombocythemia. Oncotarget. 2017 May 16; 8(20):32476-32491.
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Chang YC, Lin HC*, Chiang YH, Chen CG, Huang L, Wang WT, Cheng CC, Lin J, Chang YF, Chang MC, Hsieh RK, Chen SJ, Lim KH, Kuo YY. Targeted next-generation sequencing identified novel mutations in triple-negative myeloproliferative neoplasms. Med Oncol. 2017 May; 34(5):83.
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Lin HC*, Hwang DY, Lim KH. Targeted re-sequencing of TET2 in Taiwanese patients with myelodysplastic/myeloproliferative neoplasms. Med Oncol. 2016 Aug; 33(8):92.
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Ken-Hong Lim, Yu-Cheng Chang, Yi-Hao Chiang, Huan-Chau Lin*, Chiao-Yi Chang, Ching-Sung Lin, Ling Huang, Wei-Ting Wang, Caleb Gon-Shen Chen, Wen-Chien Chou, and Yuan-Yeh Kuo. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood Cancer Journal. 2016, Oct; 6, e481.
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K-H Lim, Y-C Chang, C Gon-Shen Chen, H-C Lin*, W-T Wang, Y-H Chiang, H-I Cheng, N-W Su, J Lin, Y-F Chang, M-C Chang, R-K Hsieh, Y-Y Ku and W-C Chou. Frequent CALR exon 9 alterations in JAK2 V617F-mutated essential thrombocythemia detected by high-resolution melting analysis. Blood Cancer Journal. 2015, Mar; 5, e295.
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Ken-Hong Lim, Huan-Chau Lin*, Yi-Hao Chiang et al. Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis. Clin Chim Acta 2015 Feb 15;440:133-9.
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Lim K-H, Lin H-C*, Chiang Y-H, Wang W-T, Lin C-S, Chang Y-C, Su N-W, Chen CG-S, Lin J, Hsieh R-K, Chang M-C, Chang Y-F, Kuo Y-Y, Chou W-C. Calr mutations in essential thrombocythemia: frequency, clinical correlation and screening by high-resolution melting analysis. Blood 2014;124:1838.
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Lin H-C*, Chen CG-S, Chang M-C, Wang W-T, Kao CW, Lo A-C, Su N-W, Chang Y-C, Chiang Y-H, Chou K-F, Liao P-N, Cai G-J, Cheng H-I, Lin J, Chang Y-F, Hsieh R-K, Lim K-H. JAK2 V617F mutation in adult Taiwanese patients with essential thrombocythemia: More prevalent in old patient and correlated with higher hemoglobin level and higher leukocyte count. International Journal of Gerontology 2013;7.
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Huan-Chau Lin*, Shu-Ching Wang, Caleb Gon-Shen Chen , Ming-Chih Chang,Wei-Ting Wang, Nai-Wen Su, Hung-I Cheng , Johnson Lin, Yi-Fang Chang , Ruey-Kuen Hsieh, Chien-Chung Chang , Yuchi Hwang, Ken-Hong Lim, Yuan-Yeh Kuo. Mutation and Lineage Analysis of DNMT3A in BCR-ABL1-negative Chronic Myeloproliferative Neoplasms. International Journal of Gerontology, 2013; 7: 186-188.
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Huan-Chau Lin*, Ken-Hong Lim, Yi-Hao Chiang et al. The Role Of tet2 DNA Methylcytosine Dioxygenase In Zebrafish Early Hematopoiesis. November 15, 2013; Blood: 122 (2).