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脊椎骨科
  • 張定國醫師相片

    張定國

    骨科 :
    台北門診掛號  淡水門診掛號

    張定國醫師本頁二維碼
  • 現職

      • 骨科部主任
      • 脊椎骨科主任
      • 高壓氧中心醫師
      • 資深主治醫師
      • 部定副教授
      • 中華民國骨科醫學會監事
      • 台灣脊椎外科醫學會理事
      • 台灣脊椎微創醫學會理事

    主要學歷

      • 陽明大學工學博士
      • 台大醫學院醫學系
      • 101年赴法 Department of Spine Surgery, CHU de Bordeaux, France
      • 103年赴南京鼓樓醫院

    主要經歷

      • 骨科專科醫師
      • 外科專科醫師
      • 中華民國高壓暨海底醫學會專科醫師
      • 台灣脊椎外科醫學會監事
      • 醫學會會員:骨科醫學會、高壓氧醫學會、脊椎外科醫學會、骨科創傷醫學會、外科醫學會、脊椎微創醫學會、關節重建醫學會

主治項目或專長


  • 一般骨科、骨折外傷、脊椎手術、脊椎微創、脊柱側彎、骨質疏鬆及骨骼疾病、高壓氧治療


論文研究

  1. Nguyen Duong Phuong Chi#, Ting-Kuo Chang#, Nguyen Bao Tran, Kuan-Ying Lai, Hsien-Te Chen, Yi-Chin Fong, Chih-Chuang Liaw,*, Chih-Hsin Tang  The natural compound ugonin V targets MMP7 production and restricts chondrosarcoma metastasis by suppressing the MEK/ERK/c-Jun signaling pathways   Journal of Functional Foods 2024; 117; 106255 (IF:3.8)
  2. Yung-Chang Lu†, Ting-Kuo Chang†, Tzu-Chiao Lin , Shu-Ting Yeh , Hung-Shih Lin , Qiao-Ping Cheng , Chun-Hsiung Huang, Hsu-Wei Fang* and Chang-Hung Huang1,2*   Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses   Journal of Orthopaedic Surgery and Research 2024; Oct 12;19(1):644. doi: 10.1186/s13018-024-05142-8 (IF:2.8)
  3. Wei‑Siang Fang, Ting‑Kuo Chang   Failure Risks of Bracing Treatment in Adolescent Idiopathic Scoliosis   Formosan Journal of Musculoskeletal Disorders 2024; 15:17-21
  4. Chih-Yuan Ko, Yen-You Lin, David Achudhan, Jun-Way Chang, Shan-Chi Liu, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Yi-Chin Fong, Hsien-Te Chen, Kun-Tsan Lee, Chien-Chung Huang, Ting-Kuo Chang* and Chih-Hsin Tang*      Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses     Int. J. Biol. Sci. 2023; 19; 5275-5289 (IF:9.2)
  5. Bao Tran Nguyen, Chih‐Yang Lin, Ting‐Kuo Chang, Yi‐Chin Fong, Louis Anoop Thadevoos, Chao‐Yang Lai, Yuan‐Li Huang, Chun‐Hao Tsai, Chih‐Yuan Ko1, Ju‐Fang Liu, Shun‐Fa Yang, Chih‐Hsin Tang      Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression  Journal of pineal research 2023; Aug;75(1):e12872.   DOI:10.1111/jpi.12872 (IF:10.3)
  6. Yu-Han Wang, Chun-Hao Tsai, Shan-Chi Liu, Hsien-Te Chen, Jun-Way Chang, Chih-Yuan Ko, Chin-Jung Hsu, Ting-Kuo Chang*, Chih-Hsin Tang*      miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy.      Frontiers in Immunology 2022; Sep 20;13:1004334    DOI:10.3389/fimmu.2022.1004334 (IF:8.786)
  7. Ting-Kuo Chang, You-Han Zhong, Shan-Chi Liu, Chien-Chung Huang,Chun-Hao Tsai, Hsiang-Ping Lee, Shih-Wei Wang, Chin-Jung Hsuand Chih-Hsin Tang      Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway     Frontiers in Immunology 2021;   DOI:10.3389/fimmu.2021.737990 (IF:7.561)
  8. Kai-Ting Chien, Ching-Chen Chen, Chien-Ming Chu, Ya-Lin Chan, Hsiu-Yun Chung, Ting-Kuo Chang*      The Determination of Efficacy of CircuCare on Blood Circulation and Metabolism: An Animal Model Study     Computational and Mathematical Methods in Medicine 2021; Volume 2021, Article ID 9934107, 8 pages  DOI:10.1155/2021/9934107 (IF:2.809)
  9. Yu-Ching Huang, Ting-Kuo Chang*      Bosworth fracture treated with immediate open reduction and internal fixation 6 hours after injury: A case report     Formosan Journal of Musculoskeletal Disorders 2020, 11 (2020) 136-140 
  10. Ting-Kuo Chang,Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang      Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways   AGING-US 2020, 2020, Vol. 12, No. 10, 9224-9239 (IF:4.831)
  11. Chen-Yu Yang, Chi Chen, Cheng-Yung Lin, Yi-Hsuan Chen, Chih-Yang Lin, Chih-Wen Chid, Yu-Jen Chen, Shih-Chia Liu, Ting-Kuo Chang, Chih-Hsin Tang, Yu-Wei Lai, Huai-Jen Tsai, Jih-Jung Chen, Shih-Wei Wang      Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells      Phytomedicine 2019, Nov;64:152911. DOI: 10.1016/j.phymed.2019.152911. Epub 2019 Apr 2. (IF:4.18)
  12. Ting-Kuo Chang, Ching-Chi Hsu      Comparison of Different Pullout Test Setups for Evaluation of Bone–Implant Interfacial Strength of Anterior Lumbar Interbody Fusion Devices     Journal of Medical and Biological Engineering 2019,   DOI: 10.1007/s40846-018-0392-z (IF:1.306)
  13. Chang TK, Ching-Chi Hsu, Ming-An Yang, and Devina Sutaji      Effects of Fusion Device Designs on Spine Biomechanics      IEEE Consumer Electronics Magazine 2019,8(2):84 - 89 (SCI,COMPUTER SCIENCE, HARDWARE & ARCHITECTL) (IF:3.273, 10/52=19.2%)
  14. Ting-Kuo Chang, Ching-Chi Hsu      Comparison of Different Pullout Test Setups for Evaluation of Bone–Implant Interfacial Strength of Anterior Lumbar Interbody Fusion Devices     Journal of Medical and Biological Engineering 2019,39(1):117-125
  15. Lai YS, Chen WC, Huang CH, Cheng CK, Chan KK, Chang TK*,      The effect of graft strength on knee laxity and graft in-situ forces after posterior cruciate ligament reconstruction,     PLOS ONE, 2015 May 22; 10(5):e0127293 (SCI, Multidisciplinary sciences)(IF:3.234, 8/56=14.2%) (Corresponding author)
  16. Lu YC, Chang TK, Yeh ST, Fang HW, Lin CY, Hsu LI, Huang CH, Huang CH.      The potential role of strontium ranelate in treating particle-induced osteolysis.     Acta Biomaterialia. 2015;20:147-154. (SCI, Engineering, Biomedical)(IF:6.025, Ranking:3/76=3.9%) (Co-first author)
  17. TING-KUO CHANG, CHING-CHI HSU*, KUAN-TING CHEN      Optimal screw orientation for the fixation of cervical degenerative disc disease using nonlinear C3-T2 multi-level spinal models and neuro-genetic algorithms      Acta of Bioengineering and Biomechanics 2015, 17(3)
  18. Chen LP, Chang TK*, Huang TY, Kowk TG, Lu YC,    “The correlation between lateral bowing angle of the femur and the location of atypical femur fractures”     Calcif Tissue Int. 2014; 95(3):240-7. (SCI, Endocrinology & Metabolism)(IF:3.272, Ranking: 55/128=43%) (Corresponding author)
  19. Ching-Chi Hsu, Ting-Kuo Chang, Dinh Cong Huy      Biomechanical Comparison of Different Vertebral Plate Designs for Anterior Cervical Discectomy and Fusion Using Nonlinear C3-T2 Multi-Level Spinal Models     Computer-Aided Design & Applications 2014,12(2) : 1–6
  20. Ting-Kuo Chang*, Chang-Hung Huang, Yueh-Ching Liu, Wen-Chuan Chen, Colin J. McClean, Yu-Shu Lai, Cheng-Kung Cheng      Biomechanical Evaluation and Comparison of Polyetheretherketone Rod System to Traditional Titanium Rod Fixation on Adjacent Levels     Formosan Journal of Musculoskeletal Disorders 2013, 4(2):42-47